Transplacental exposure from dams injected with Strontium-90 1 to 9 Days prepartum

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In 1956 [[Miriam P Finkel]] performed one of several [[Beagle Dog Experiments]] at [[Argonne National Laboratory]]. Finkel perfomed transplacental exposure of dams injected with Strontium-90 1 to 9 Days prepartum to investigate health risks in beagles for extrapolation to possible effects on children born to mothers exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.
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== Red Book Description ==
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Copied from: Roy C Thompson. <i>Life-Span Effects of Ionizing Radiation in the Beagle Dog</i> (1989) ([http://janus.northwestern.edu/dog_tissues/reports/red_book.pdf link pdf])
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Transplacental exposure from dams injected with 90Sr at 1 to 9 days prepartum. Results as of January 10, 1971 (Finkel, 1972).
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{| border="1" cellpadding="20" cellspacing="0"
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| Burden at Birth (uCi/kg)
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| No. of Animals Dead
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| Median Age at Death ( years )
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| Bone Tumor number
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| Bone Tumor % incidence
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|-
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| None (control)
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| 9
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| &gt; 8
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| 0
 +
| ( 0 )
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|-
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| 7 to 41
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| 5
 +
| &gt; 11
 +
| 0
 +
| ( 0 )
 +
|-
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| 120 to 300
 +
| 9
 +
| 4.3
 +
| 8
 +
| ( 89 )
 +
|}
 +
 
 +
 
 +
A single report describes early results of this study (Finkel, 1972). Initial burdens were determined by whole-body bremsstrahlung measurement at birth. High-level litters were from dams injected with 100 pCi/kg 90Sr (in equilibrium with Y-90) 8 days before delivery. Low-level litters were from dams injected with 10 to 15 pCi/kg 1 to 9 days before delivery. Controls are general colony controls. Final results have not been published.
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Information relevant to this experiment will be found in the following Argonne National Laboratory periodic reports:
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*1959 (Dec) ANL-6093 15-19
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*1961 (Nov) ANL-6464 38-49 [[Media:1961 Nov ANL-6464.pdf]]
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== Gray Book Description ==
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Copied from: GB Gerber, CR Watson, T Sugahara, and S Okada. <i>International Radiobiology Archives of Long-Term Animal Studies
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I. Descriptions of Participating Institutions and Studies</i> (1996) ([http://janus.northwestern.edu/dog_tissues/reports/grey%20book.pdf])
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'''Institution:''' Argonne National Laboratory, Argonne IL
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''' Scientists: ''' Miriam P Finkel; retired
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''' Purpose ''' Investigate health risks in beagles for extrapolation to possible effects on children born to mothers exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.
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''' Status ''' Injection of strontium-90 in 1956, results unpublished. Copies of laboratory record books are available at NRA.
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''' Treatment ''' Beagle dogs exposed by transplacental exposure from dams injected with strontium-90 chloride.
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''' Endpoints '''
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''' Animal ''' 53 Beagle dogs at 1 to 9 d prepartum in 3 groups.
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''' Results '''
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''' References '''
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''' Experimental Groups ''' Study 103.01 Life-Span Health Risks: Transplacental Strontium-90 in Immature (1- to 9-Day-Prepartum) Beagles
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{| border="1" cellpadding="20" cellspacing="0"
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| Group Id
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| Burden at birth (MBq/kg)
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| Number of Dogs
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|-
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| 01
 +
| Control
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| 29
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|-
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| 02
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| 0.259 to 1.517
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| 15
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|-
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| 03
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| 16.440 to 11.100
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| 9
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|-
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| Total
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|
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| 53
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|}
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==References==
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*Finkel M.P., Biskis B.O., Greco I. and Camden R.W. 1972. Strontium-90 toxicity in dogs: Status of Argonne study on influence of age and dosage pattern. In Biomedical Implications of Radiostrontium Exposure (M. Goldman and L.K. Bustad, eds., CONF-710201, NTIS, Springfield, VA) 285-312.

Revision as of 18:08, 13 December 2010

In 1956 Miriam P Finkel performed one of several Beagle Dog Experiments at Argonne National Laboratory. Finkel perfomed transplacental exposure of dams injected with Strontium-90 1 to 9 Days prepartum to investigate health risks in beagles for extrapolation to possible effects on children born to mothers exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.

Red Book Description

Copied from: Roy C Thompson. Life-Span Effects of Ionizing Radiation in the Beagle Dog (1989) (link pdf)

Transplacental exposure from dams injected with 90Sr at 1 to 9 days prepartum. Results as of January 10, 1971 (Finkel, 1972).

Burden at Birth (uCi/kg) No. of Animals Dead Median Age at Death ( years ) Bone Tumor number Bone Tumor % incidence
None (control) 9 > 8 0 ( 0 )
7 to 41 5 > 11 0 ( 0 )
120 to 300 9 4.3 8 ( 89 )


A single report describes early results of this study (Finkel, 1972). Initial burdens were determined by whole-body bremsstrahlung measurement at birth. High-level litters were from dams injected with 100 pCi/kg 90Sr (in equilibrium with Y-90) 8 days before delivery. Low-level litters were from dams injected with 10 to 15 pCi/kg 1 to 9 days before delivery. Controls are general colony controls. Final results have not been published.

Information relevant to this experiment will be found in the following Argonne National Laboratory periodic reports:


Gray Book Description

Copied from: GB Gerber, CR Watson, T Sugahara, and S Okada. International Radiobiology Archives of Long-Term Animal Studies I. Descriptions of Participating Institutions and Studies (1996) ([1])

Institution: Argonne National Laboratory, Argonne IL

Scientists: Miriam P Finkel; retired

Purpose Investigate health risks in beagles for extrapolation to possible effects on children born to mothers exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.

Status Injection of strontium-90 in 1956, results unpublished. Copies of laboratory record books are available at NRA.

Treatment Beagle dogs exposed by transplacental exposure from dams injected with strontium-90 chloride.

Endpoints

Animal 53 Beagle dogs at 1 to 9 d prepartum in 3 groups.

Results

References

Experimental Groups Study 103.01 Life-Span Health Risks: Transplacental Strontium-90 in Immature (1- to 9-Day-Prepartum) Beagles

Group Id Burden at birth (MBq/kg) Number of Dogs
01 Control 29
02 0.259 to 1.517 15
03 16.440 to 11.100 9
Total 53

References

  • Finkel M.P., Biskis B.O., Greco I. and Camden R.W. 1972. Strontium-90 toxicity in dogs: Status of Argonne study on influence of age and dosage pattern. In Biomedical Implications of Radiostrontium Exposure (M. Goldman and L.K. Bustad, eds., CONF-710201, NTIS, Springfield, VA) 285-312.
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