Inhalation Toxicology Research Institute

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The Inhalation Toxicology Research Institute (ITRI) is one of the many participating institutions where radiobiology experiments were performed. A full list of ITRI's Lovelace reports is available through Northwestern's Beagle Dog Archive [[1]]

Gray Book Description

Copied from: GB Gerber, CR Watson, T Sugahara, and S Okada. International Radiobiology Archives of Long-Term Animal Studies I. Descriptions of Participating Institutions and Studies (1996) ([2])

Inhalation Toxicology Research Institute (ITRI), Lovelace Biomedical and Environmental Research, PO Box 5890, Albuquerque, NM 87185-5890, USA, Tel. 505-845-1090, Fax: 505-845-1198

Contact Person: Dr. Bruce Boecker

The Inhalation Toxicology Research Institute (ITRI) is operated by the Lovelace Biomedical and Environmental Research Institute; early publications cite Lovelace as the institution at which the research was performed. ITRI is the largest DOE-supported laboratory dedicated to the study of basic inhalation toxicology. Studies cover the entire range of biological systems, including macromolecules, cells, tissues, laboratory animals, and humans.

ITRI has conducted dog life-span experiments on a variety of fission products including yttrium-90, strontium-90, yttrium-91, cesium-137, and cerium-144, radionuclides that predominate in a reactor inventory after a period of sustained operation. Subsequently, investigations were extended to include plutonium-238 and 239 dioxide. The dosimetry and pathogenesis of disease for inhaled radionuclides were studied for a broad range of α-, β-, and γ-emitting radionuclides in different physical and chemical forms. Long-term rodent studies at ITRI include repeated inhalation exposures of plutonium-239or cerium-144 oxide , combined exposures of plutonium-239 oxide and 1) X-rays, 2) inhaled beryllium metal aerosols, 3) inhaled cigarette smoke, or 4) injected chemical carcinogens. Additional long-term studies have involved inhaled curium-244 oxide, injected Thorotrast and plutonium-239 citrate. Materials from these studies are available at ITRI; electronic copies of database files are available throuth the National Radiobiology Archives at PNL.

Investigators associated with the ITRI long-term radiobiology studies were (in alphabetic order): S.A. Benjamin, M.A. Berry, B.B. Boecker, A.L. Brooks, T.L. Chiffelle, R.G. Cuddihy, J.H. Diel, G.L. Finch, N.A. Gillett, W.C. Griffith, R.A. Guilmette, F.F. Hahn, C.H. Hobbs, R.K. Jones, S.E. Jones, G. Kanapilly, D.L. Lundgren, J.L. Mauderly, R.O. McClellan, T.T. Mercer, J.A. Mewhinney, B.A. Muggenburg, G.J. Newton, K.J. Nikula, J.A. Pickrell, O.G. Raabe, H.C. Redman, B.R. Scott, D.O. Slauson, M.B. Snipes, and R.G. Thomas.

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