Beagle Dog Experiments

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The Phantom Beagle Dog from Argonne National Laboratory.

Contents

Overview

The Beagle Dog Experiments were carried out at a variety of National Laboratories. The Beagle Dog was chosen as an experimental animal because of its size and long lifespan. In addition to the material provided below, there are several comprehensive reviews which cover the beagle dog experiments, Roy C. Thompson's "Life-Span Effects of Ionizing Radiation in the Beagle Dog" [1] and the "International Radiobiology Archives of Long-Term Animal Studies I. Descriptions of Participating Institutions and Studies" by Gerber, Watson, Sugahara, and Okada [2].

Several researchers have compared the results of multiple Beagle Dog studies including the following:

  • Two-Mutation Models for Bone Cancer due to Radium, Strontium, and Plutonium. by Harmen Bijwaard, Marco J. P. Brugmans, and Henk P. Leenhouts. pubmed
  • Bone Cancer Risk of Plutonium 239 in Humans Derived from Animal Models. by Harmen Bijwaard and Fieke Dekkers. pubmed

In 2010 many researchers currently and historically involved in the beagle dog studies assembled in Richland Washington for the Beagle Data Congress. Recordings from these sessions are available.


Argonne Experiments

The Argonne Beagle Dog Experiments, carried out at Argonne National Laboratory from 1952 to 1991 and supported by grants from the Atomic Energy Commission, investigated the effects of Cobalt-60 radiation on nearly 5000 beagle dogs. The tissues from these studies continue to be analyzed by immunohistochemical techniques and xfm pdf. Data and tissues from the Argonne Beagle dog Experiments is available through the Beagle Dog Archive [3] hosted at the Woloschak Laboratory [4]. Some recent statistical work has been performed across studies on the Argonne Beagle dog studies including an analysis of the prostate incidence at various dose and dose rates pdf.

Endpoints

Data were collected from the beagle dogs on a variety of endpoints including pathologies, clinical blood records, lifespan, breeding records and so on.

  • Pathologies
    • Complete pathological reports were recorded for each dog using the SNODOG ontology [5].
    • Pathologists were selected to perform autopsies as they were available. That is there was no bias in the pairing of pathologist with dog.

List of Experiments

The Argonne Beagle Dog Experiments consisted of 15 unique studies. These studies are listed below along with what material has been archived from the experiment.

Study Number of Animals Information Available Description
Transplacental exposure from dams injected with Strontium-90 1 to 9 Days prepartum 53 summary Transplacental exposure of dams injected with Strontium-90 1 to 9 Days prepartum to investigate health risks in beagles for extrapolation to possible effects on children born to mothers exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.
Daily injections Strontium-90 99 summary The health risks in beagles for extrapolation to possible effects on humans continuously exposed to strontium-90 from fallout from atmospheric nuclear weapons testing.
Single intravenous injection of cerium citrate solution 49 summary and data Single intravenous injection of cerium-144 citrate solution to 49 Beagle dogs (11 females, 38 males), "approximately 13 mo" of age in order to study the long-term effects of soluble Ce-144.
Single intravenous injection of cesium solution 80 summary Single intravenous injection of cesium solution; dogs of various ages, of both sexes in order to examine the organs and tissues at risk following the internal deposition of cesium-137 and determine the influence of age at exposure on these risk patterns.
External Co-60 gamma-ray exposure, continued until death 295 summary, data, and tissues External Co-60 gamma-ray exposure at dose rates ranging from 0.3 to 54 cGy/day, continued until death on 13 months old dogs of both sexes
Continuous external Co-60 gamma-ray exposure, at various dose rates, terminated at various total doses 343 summary, data, and tissues exposed dogs to 22 h/d external cobalt-60 gamma-ray, at dose rates ranging from 3.8 to 26.3 cGy per day, terminated at total doses ranging from 450 to 3000 cGy in order to investigate the effect of total dose and dose rate in beagles given protracted whole-body cobalt-60 gamma ray exposure
Leukemogenesis: Duration-of-Life Gamma-Irradiation of Young Adult Beagles 27 summary, data, and tissues Duration of life external cobalt-60 gamma ray exposure, 22 hrs/d at 75 mGy/d in order to investigate the consequences of duration-of-life exposure at low dose rates on leukaemogenesis.
Gamma-ray exposure during pregnancy 298 summary, data, and tissues the general health effects of daily Co-60 exposure ranging from 1 to 26 cGy per day on pups during pregnancy.
Lithium and Potassium Study 13 data and tissues not available
Various Studies Dealing with Hematological Changes 130 data and tissues not available
Various Studies after Acute Exposure and Effects on Reticuloendothelial System 150 data and tissues not available
Various Studies Dealing with the Thyroid, the Adrenal and the Action of RadioIodine 130 data and tissues not available
Various Studies Dealing with the Development of Different Techniques and Procedures 247 data and tissues not available
Various Groups from Stock, Breeders etc. 2619 data and tissues not available
Consequences to Man of an Exposure to Ra-226 data
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