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Synopsis


The Janus Experiments, carried out at Argonne National Laboratory from 1972 to 1989 and supported by grants from the US Department of Energy, investigated the effects of neutron and gamma radiation on mouse tissues primarily from B6CF1 mice.


Highlights

  • 49,000 mice were irradiated: Death records were recorded for 42,000 mice; gross pathologies were recorded for 39,000 mice; and paraffin embedded tissues were preserved for most mice
  • Mouse record details type and source of radiation [gamma, neutrons]; dose and dose rate [including life span irradiation]; type and presence/absence of radioprotector treatment; tissue/animal morphology and pathology
  • Total doses of 90-5111 cGy gamma rays, or 1-320 cGy neutrons
  • Protracted low dose rate treatments, short term higher dose rate treatments, variable dose rates with a same total dose, etc. in some cases in conjunction with radioprotectors
  • Normal tissues, tumors, metastases were preserved
  • Standard tissues saved: lung, liver, spleen, kidney, heart, any with gross lesions (including mammary glands, Harderian gland with eye, adrenal gland, gut, ovaries or testes, brain and pituitary, bone)

Full Documentation


To learn more about the studies, please refer to the janus documentation. More information can be found in the Argonne Annual Reports and in the list of publications maintained on our wiki.

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